Viral protease cleavage of inhibitor of B triggers host cell apoptosis

Viral protease cleavage of inhibitor of B triggers host cell apoptosis

*Fundación Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernandez Almagro 3, 28029 Madrid, Spain; ‡Departamento de Fisiologia, Facultad de Medicina, Universidad de Alcala, Carretera Barcelona Km 33, 28017 Alcala de Henares, Spain; §Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 950, Baltimore, MD 21205; and ¶...

Dengue Viral Protease Interaction with NF-kB Inhibitor a/b Results in Endothelial Cell Apoptosis and Hemorrhage Development

Cleavage of host keratin 8 by a Chlamydia-secreted protease.

Chlamydiae have to replicate within a cytoplasmic vacuole in eukaryotic cells. Expansion of the chlamydia-laden vacuole is essential for chlamydial intravacuolar replication, which inevitably causes host cell cytoskeleton rearrangements. A cleavage fragment of keratin 8 corresponding to the central rod region was detected in the soluble fraction of chlamydia-infected cells. Since keratin 8 is a...

Granzyme M-Mediated Cleavage of Viral Replication through NK Cell Protease Noncytotoxic Inhibition of Cytomegalovirus

Dengue viral protease interaction with NF-κB inhibitor α/β results in endothelial cell apoptosis and hemorrhage development.

Hemorrhagic manifestations occur frequently accompanying a wide range of dengue disease syndromes. Much work has focused on the contribution of immune factors to the pathogenesis of hemorrhage, but how dengue virus (DENV) participates in the pathogenic process has never been explored. Although there is no consensus that apoptosis is the basis of vascular permeability in human dengue infections,...